Immunohematology Reference Laboratory Services

The Miller-Keystone Blood Center Immunohematology Reference Laboratory is an AABB (Association for Advancement of Blood and Biotherapies) -accredited laboratory that specializes in the identification and resolution of red cell transfusion compatibility problems.

Hospitals and blood centers throughout the country can utilize the services of the Reference Laboratory routinely for simple
to complex serologic investigations and the provision of specialty typed red cell units for patients with a transfusion need.

The available tests and services performed in the Reference Laboratory
are outlined below:

  • Simple and Complex Antibody Resolution
    • Warm and Cold Auto-Antibodies
    • Antibodies to High and Low-Incidence Antigens
    • Antibodies demonstrating High-Titer, Low-Avidity characteristics
    • Drug-induced Antibodies
    • Reagent-Dependent Reactivity
  • Hemolytic Disease of the Newborn Investigations
  • Transfusion Reaction Investigations
  • Aberrant or Discrepant Result Investigations
    • ABO Discrepancies
    • Discrepant Red Cell Antigen Typing
    • Weak Antigen Expression Investigations
  • Polyagglutination Investigation
  • Donor/Patient Extended Red Cell Phenotype Requests
  • Prenatal Evaluations (ABO/Rh, Antibody ID, Titer)
  • Platelet Antibody Screening and “Crossmatch Compatible” Platelets
  • Serologic Consultations
  • Procurement of Antigen-Negative Donor Units
  • Response to Requests for Rare Donor Units from the American Rare Donor Program (ARDP)
  • Antibody ID of antibody positive donors